Abstract:

There is still a need for research to understand the co- herences of the origin of arrhythmias such like rotors and possible ablation strategies. The aim of this work was the analysis of typical signal characteristics near a rotor cen- ter. Rotors were simulated on 2D patch geometry (100 mm x 100 mm) with spatial resolution of 0.1mm. Based on extracellular potentials, different features were evalu- ated: Local activation time, peak to peak amplitude, steep- est negative slope and approximate entropy were com- pared regarding their ability to indicate the rotor tip lo- cation. Furthermore, typical signal patterns of different mapping catheters centered at the rotor tip position were analyzed. The determined maximum distances between the focal point of phase singularities and determined centers by the peak to peak amplitudes were maximal 1.7 mm.

Abstract:

Direction of propagation (DOP) and conduction velocity (CV) of excitation waves are essential parameters to identify targets for catheter ablation of cardiac arrhythmias. Most approaches to determine the DOP and CV rely on manual anno- tation. Many, time-consuming measurements with mapping catheters are required. Aim of this work was to quantitatively extract the DOP and the CV of wavefronts from intracardiac electrograms with a single shot measurement. We used a simulation database of planar waves computed with a cellular automaton with different CVs between 500 mm/s and 1100 mm/s. By comparing the correct values of CV and DOP with the computed values from the developed algorithm the median CV- error was between 7 mm/s and 50 mm/s and the median DOP- error variated between 1\0 and 4\0.