Institute of Biomedical Engineering (IBT)

IBT Publications by Seemann of the year 2005

Journal Articles (2)

I. M. Graf, O. Dössel, G. Seemann, and D. L. Weiss.
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts.
In Medical & Biological Engineering & Computing, vol. 43(6) , pp. 783-792, 2005

Abstract:

The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation (Ito, IKs and IKI) were reduced by 25%. Successively, [Na+]i was increased by the regulation of the Na+-Ca2+ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features.

D. L. Weiss, O. Dössel, G. Seemann, and F. B. Sachse.
Modelling of the short QT syndrome in a heterogeneous model of the human ventricular wall.
In Europace, vol. 7s2, pp. 105-117, 2005

Conference Contributions (16)

K. Albrecht, O. Dössel, M. Reumann, G. Seemann, G. Reinerth, and C. F. Vahl.
Computer-aided Evaluation and Optimisation of Biventricular Pacing for Patients with Congestive Heart Failure.
In Biomedizinische Technik, vol. 50(1) , pp. 701-702, 2005

J. Buchta, D. L. Weiss, O. Dössel, and G. Seemann.
Effects of Mutations on Human Cardiac Electrophysiology: A Computational Analysis.
In Biomedizinische Technik, vol. 50(1) , pp. 562-563, 2005

K. Chaisaowong, F. B. Sachse, and G. Seemann.
Computational Modeling of Cellular Force Development in the Human Heart.
In Proc. 1st Annual Mountain West Biomedical Engineering Conference, 2005

K. Chaisaowong, F. B. Sachse, and G. Seemann.
Modeling of human cardiac force development: I. Adjustment of an electrophysiological model to approach specimen-specific properties of myocytes.
In Proc. 2nd ECTI Annual Conference, pp. 811-814, 2005

H. Chen, D. L. Weiss, O. Dössel, and G. Seemann.
Simulated Electromechanical Heterogeneity in Human Left Ventricle.
In Biomedizinische Technik, vol. 50(1) , pp. 564-565, 2005

M. B. Mohr, R. R. Schnell, O. Dössel, G. Seemann, and F. B. Sachse.
Incorporating blood pressure load into an elastomechanical ventricular model.
In Computers in Cardiology, Lyon, France, 2005

M. B. Mohr, O. Dössel, G. Seemann, and F. B. Sachse.
Enhancing numerical stability of an electromechanical ventricular model.
In Biomedizinische Technik(50) , pp. 548-549, 2005

O. Dössel, M. Reumann, J. Bohnert, G. Seemann, B. Osswald, and S. Hagl.
Atrial fibrillation in a computer model of the visible female heart for planning of surgical intervention.
In Biomedizinische Technik, vol. 50(1) , pp. 699-700, 2005

F. B. Sachse, G. Seemann, and B. Taccardi.
Insights into Electrophysiological Studies with Papillary Muscle by Computational Models.
In Lecture Notes in Computer Science, vol. 3504, pp. 216-225, 2005

O. Dössel, G. Seemann, D. L. Weiss, and F. B. Sachse.
Interaction of the Human Sinoatrial Node with Surrounding Atrial Tissue: A Simulation Study.
In Biomedizinische Technik(50) , pp. 560-561, 2005

O. Dössel, G. Seemann, D. L. Weiß, and F. B. Sachse.
Electrophysiology and Tension Development in a Transmural Heterogeneous Model of the Visible Female Left Ventricle.
In Lecture Notes in Computer Science, vol. 3504, pp. 172-182, 2005

O. Dössel, G. Seemann, H. Ying, D. L. Weiss, and F. B. Sachse.
Effects of Electrophysiological Remodeling in Human Right Atrium: A Simulation Study.
In Proc. Computers in Cardiology, vol. 32, pp. 69-72, 2005

D. L. Weiss, O. Dössel, and G. Seemann.
Efficient Solving of Mathematical Models Describing the Behavior of Cardiac Myocytes.
In Biomedizinische Technik, vol. 50(1) , pp. 566-567, 2005

D. L. Weiss, O. Dössel, and G. Seemann.
Epicardial stimulation of a virtual left ventricular wall comprising heterogeneity and anisotropy.
In Proc. IFMBE / EMBEC, vol. 11, 2005

D. L. Weiss, O. Dössel, G. Seemann, and F. B. Sachse.
Epicardial Activation Increases Transmural Dispersion of Repolarization in a Heterogeneous Model of Wild-Type and Short QT Mutant Tissue.
In Proc. Computers in Cardiology, vol. 32, pp. 117-120, 2005

D. L. Weiß, O. Dössel, G. Seemann, and F. B. Sachse.
Impact of genetic defects on the electrical properties of the heterogeneous ventricular wall.
In 346. Heraeus-Seminar, 2005

Dissertations (1)

G. Seemann.
Modeling of electrophysiology and tension development in the human heart.
Institut für Biomedizinische Technik. Dissertation. 2005