F. B. Sachse, G. Seemann, and C. D. Werner. Combining the Electrical and Mechanical Functions of the Heart. In Int. J. Bioelectromagnetism, vol. 3(2) , 2001
Abstract:
Computer aided simulations of the heart provide knowledge for cardiologic diagnosis and therapy. A model of the myocardium is presented which allows the reconstruction of electrical and mechanical processes with inclusion of feedback mechanisms. The model combines detailed models of cellular electrophysiology and force development with models of the electrical current flow and the mechanical behavior of the myocardium. Results of simulations show the connection between the electrical excitation process and the following mechanical deformation in a three dimensional, anisotropic area of the myocardium. Keywords: Mechano-Electrical Feedback, Electro-Mechanical Feedback, Cellular Models, Electrophysiology, Excitation-Propagation
Book Chapters (1)
F. B. Sachse, C. D. Werner, and G. Seemann. Simulation of Cardiac Electrophysiology and Electrocardiography. In Computer Simulation and Experimental Assessment of Cardiac Electrophysiology, Futura Publishing, Armonk, New York, pp. 97-104, 2001
Conference Contributions (14)
S. Barros, N. S. Couto, F. B. Sachse, C. D. Werner, and G. Seemann. Segmentation and tissue-classification of the visible female dataset - thoracic muscles, bones and blood vessels. In Biomedizinische Technik, vol. 46-1, pp. 510-511, 2001
L. G. Blümcke, F. B. Sachse, O. Dössel, G. Seemann, and C. D. Werner. Entwicklung eines schnellen Verfahrens zur Deformation im Herzen ausgehend von makroskopischen Modellen der Kraftentwicklung. In Biomedizinische Technik, vol. 46-1, pp. 516-517, 2001
Knowledge of tissue distribution allows the creation of anatomical models of the human body. Anatomically based models are of increasing interest e.g. in the field of medical education, development of therapies and research on the risks of electro smog.The motivation for this work was the creation of a female 3D anatomical model with high accuracy and resolution. The purpose of this anatomical model is to simulate the human physical behavior through the numerical calculation of fields.The objectives were the segmentation of the Visible Female thorax applying digital image processing techniques and the evaluation of existing tools for segmentation and classification. This evaluation should deliver solutions to achieve better accuracy, to reduce the time on manual segmentation and to allow an adaptation of existing tools.
M. Jösel, F. B. Sachse, O. Dössel, G. Seemann, and C. D. Werner. Simulation der Katheterisierung und Radio-Frequenz-Ablation in der Kardiologie mit einem haptischen Interface. In Biomedizinische Technik, vol. 46-1, pp. 528-529, 2001
M. B. Mohr, F. B. Sachse, O. Dössel, G. Seemann, and C. D. Werner. Vergleich von mikroskopischen und makroskopischen Modellen der Kraftentwicklung und Deformation im Myokard. In Biomedizinische Technik, vol. 46-1, pp. 524-525, 2001
F. B. Sachse, C. Riedel, C. D. Werner, and G. Seemann. Stretch activated ion channels in myocytes: Parameter estimation, simulations and phenomena. In Proc. IEEE EMBS, vol. 1, pp. 52-55, 2001
F. B. Sachse, C. D. Werner, and G. Seemann. Anatomical models of the heart for the simulation of excitation propagation and force development. In Annals of Biomedical Engineering, pp. 48, 2001
O. Dössel, G. Seemann, F. B. Sachse, and C. D. Werner. Simulation der Kraftentwicklung im Myokard bei physiologischer und pathologischer Erregungsausbreitung. In Biomedizinische Technik, vol. 46-1, pp. 192-193, 2001
M. Thüringer, F. B. Sachse, O. Dössel, G. Seemann, and C. D. Werner. Simulation der Deformation im Myokard ausgehend von mikroskopischen Modellen der Kraftentwicklung und hyperelastischen Materialbeschreibungen. In Biomedizinische Technik, vol. 46-1, pp. 526-527, 2001