O. Molchanova. Development and Characterization of a SDOCT System for Imaging Scattering Samples. Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT). Bachelorarbeit. 2018
Optical Coherence Tomography (OCT) is a noninvasive, label-free imaging modality. It has been widely used in medical imaging due to its unique characteristics in resolution and penetration depth. OCT has larger penetration depth than confocal microscopy and resolution higher than ultrasound imaging systems. The goal for this project was to develop and characterize a Spectral Domain Optical Co- herence Tomography (SDOCT) system. Graphical User Interface (GUI) was developed to improve the system in terms of signal acquisition and online reconstruction of the depth re- flectivity profile (A-scan). Dispersion compensation was realized by retrieving the nonlinear compartment of the phase, introducing the dispersion term and correcting the signal by this term. Developed system was characterised with axial resolution, Signal to Noise Ratio (SNR) and signal drop-off. After dispersion compensation axial resolution improved twofold and reached the value of 13.7 μm and SNR value increased by 6 dB. To investigate OCT signal in a scattering environment, experiments with Intralipid solution were conducted.