G. Lenis, H. G. Jahnke, and O. Dössel. An algorithm to analyze extracellular field potentials measured from cardiac myocytes. In Biosignalverarbeitung und Magnetische Methoden in der Medizin, 2014
For the purpose of accurate preclinical drug screening and particularly to evaluate the risk of undesired cardiac arrhyth- mias or drug induced toxicity, human embryonic stem cell derived cardiomyocytes clusters can be used. A novelty micrcocavity array screening platform has been developed to facilitate recordings of extracellular field potentials and de- tect QT prolongation and cardiotoxic effects. The measured signal is similar to a human ECG with a missing P wave. In order to automate the drug screening process and delineate the filed potential recordings a signal-analyzing algorithm has been developed.